Inisghts into DHP Induced Cortisol Response in Head Kidney of Rainbow Trout (Oncorhynchus mykiss)
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There are numerous reports of stress negatively impacting reproductive efforts in animals. Yet, the physiological mechanism behind this is unclear. Previous research suggests that the reproductive stage of rainbow trout (Oncorhynchus mykiss) impacts the animal’s sensitivity to stress, which can be directly measured through cortisol synthesis. Furthermore, 7α,20β-dihydroxy-4-pregnen-3-one (DHP), a maturation inducing hormone that regulates late-stage development, increased the in vitro production of cortisol via ACTH-stimulated head kidney. However, the way in which DHP affects cortisol synthesis is unknown. There are several key molecules involved in cortisol production. These include: cholesterol side chain cleavage enzyme (P450scc), 11β hydroxylase (11βH), melanocortin 2 receptor (MC2R) and steroidal acute regulatory protein (StAR). This study investigates how DHP affects these compounds during cortisol biosynthesis. Elucidation of the mechanisms connecting stress and reproduction in fish will likely be applicable to all vertebrates, and can help lead to novel insights into preventing stress-related reproductive disorders.